1.  Dr. Emmet Brown: Roads? Where we're going we don't need roads.
Back To The Future

2.  Paperboy: I want my two dollars!
Better Off Dead

3.  CC Bloom: It looks like a flamingo threw up in here!
Beaches

4.  John Bender: Does Barry Manilow know that you raid his wardrobe?
The Breakfast Club

5.  Grace: Oh, he's very popular Ed. The sportos, the motorheads, geeks, sluts, bloods, waistoids, dweebies, dickheads--they all adore him. They think he's a righteous dude.
Ferris Bueller’s Day Off

6.  Raymond Babbitt: K-Mart Sucks.
Rain Man

7.  Vern Tessio: : If I could only have one food for the rest of my life? That's easy. Cherry Pez. Cherry flavor Pez. There's no doubt about it.
Stand By Me

8.  Duckie: May I admire you again today?
Pretty In Pink

9.  Pee Wee: I meant to do that.
Pee Wee’s Big Adventure

10.  Harry Doyle: Heywood leads the league in most offensive categories, including nose hair. When this guy sneezes, he looks like a party favor.
Major League

11. Michael Kellam: How can something so small make so much of something so disgusting?
Three Men & A Baby

12.  Momma: Owen doesn't have a friend!
Throw Mama From The Train

13.  Michael Dorsey: I was a better man with you as a woman than I ever was with a woman as a man.
Tootsie

14.  Maverick: I think I'll go make a fool of myself with Goose.
Top Gun